发明Methods of treating cancer

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申请号 US20070853700 申请日 2007年09月11日 最早公开日 2008年05月22日 所属国家/地区 美国
公开号及公开日 US2008119562A1   2008年05月22日
US7732490B2   2010年06月08日
授权日 2010年06月08日 说明书附图
申请人 RICHON VICTORIA M (美国)  
CHIAO JUDY H (美国)  
KELLY WILLIAM KEVIN (美国)  
MILLER THOMAS A (美国)  
发明人 RICHON VICTORIA M   CHIAO JUDY H   KELLY WILLIAM KEVIN   MILLER THOMAS A  
优先权 US20020361759P   20020304US20030379149   20030304US20070853700   20070911
专利分类号 A01N37/28   A61K9/48   A61K31/13   A61K31/16   A61K31/165   A61K31/19   A61K31/426   A61K31/44   A61K31/4402   A61K31/4406   A61K31/4409   A61K31/445   A61K31/4706   A61K31/4709   A61K38/12   A61K47/12   A61K47/38   A61P35/00   A61P43/00   C07C259/04   G01N33/579   A61K31/164  
代理机构   代理人

名称及摘要

Methods of treating cancer
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
Methods of treating cancer
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.

同族及引用

同族专利 (47) 引用其他专利(53) 被其他专利引用(73)

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Methods of treating cancer with HDAC inhibitors
Polymorphs of suberoylanilide hydroxamic acid
Polymorphs of suberoylanilide hydroxamic acid
Methods of using saha and bortezomib for treating cancer
Method of treating cancers with SAHA and Pemetrexed
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Methods of treating Hodgkin's and non-Hodgkin's lymphoma
SYSTEMS AND METHODS FOR IMPROVING BIOMARKER AVAILABILITY
METHODS OF IDENTIFYING BIOMARKERS FOR CANCER
Systems and methods of screening biomarkers in bodily fluids
METHODS OF DETERMINING STABILIZATION COMPOUNDS FOR PREDICTIVE BIOMARKERS
Methods for determining the efficiency of a therapeutic
SYSTEMS AND METHODS FOR DETERMINING THERAPEUTIC POTENTIAL
BIOMARKER STABILIZING AGENTS
SAMPLE CONTAINER FOR BIOMARKER MAINTENANCE
DEVICES AND SYSTEMS FOR BIOMARKER DETECTION
TRANSPORT CONTAINER FOR STABILIZED LIQUID SAMPLES
DEVICES AND SYSTEMS FOR BIOMARKER DETECTION
DEVICES FOR COLLECTION AND STABILIZATION OF BIOMARKERS IN LIQUID SAMPLES
DEVICES FOR COLLECTION AND STABILIZATION OF BIOMARKERS IN LIQUID SAMPLES
RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
DRINK MIXTURE FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
SYSTEMS AND METHODS FOR DETECTING INSULIN RESISTANCE BIOMARKERS
Systems and methods for biomarker analysis
SYSTEMS AND METHODS FOR THE INHIBITION OF GALACTOSE OXIDASE
SYSTEMS FOR ANALYZING STABILIZED BIOMARKERS
SYSTEMS AND METHODS OF ANALYZING BIOMARKER LEVELS
Systems and methods for hemoglobin analysis
SYSTEMS AND METHODS FOR DIAGNOSING CANCER
SYSTEMS AND METHODS FOR DETERMINING FOOD ALLERGIES
Systems and methods for the detection of biomarkers
SYSTEMS AND METHODS FOR DETERMINING CARDIAC CONDITIONS
Systems and methods for the detection of biomarkers
SYSTEMS AND METHODS FOR IDENTIFYING ALLERGIES
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SYSTEMS AND METHODS FOR DETECTING PREGNANCY
SYSTEMS AND METHODS FOR DETERMINING CALCIUM LEVELS
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DEVICES, SYSTEMS, AND METHODS FOR BIOMARKER STABILIZATION
DEVICES AND WASHES FOR BIOMARKER STABILIZATION
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NOVEL POTENT INDUCERS OF THERMAL DIFFERENTIATION AND METHOD OF USE THEREOF
Potent inducers of terminal differentiation and methods of use thereof
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Potent inducers of terminal differentiation and methods of use thereof
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Uses of hydroxy and ether-containing oxyalkylene esters for treating metabolic conditions
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Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
NOVEL CLASS OF CYTODIFFERENTIATING AGENTS AND HISTONE DEACETYLASE INHIBITORS, AND METHODS OF USE THEREOF
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Methods of inducing terminal differentiation
METHODS OF INDUCING TERMINAL DIFFERENTIATION
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Polymorphs of suberoylanilide hydroxamic acid
Methods of treating cancer with HDAC inhibitors
Methods of treating mesothelioma with suberoylanilide hydroxamic acid
Methods of treating cancer with HDAC inhibitors
Methods of treating cancer with HDAC inhibitors
Treatment of lung cells with histone deacetylase inhibitors
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Methods of treating cancer with HDAC inhibitors
Methods of treating cancer with HDAC inhibitors
COMBINATION METHODS OF SAHA AND TARGRETIN FOR TREATING CANCER
Method of treating cancers with SAHA and pemetrexed
Methods of using SAHA and Bortezomib for treating cancer
METHODS OF TREATING CANCERS WITH SAHA, CARBOPLATIN, AND PACLITAXEL AND OTHER COMBINATION THERAPIES
Methods of treating cancer with HDAC inhibitors
Polymorphs of suberoylanilide hydroxamic acid
Methods of treating cancer with HDAC inhibitors
Polymorphs of suberoylanilide hydroxamic acid
Polymorphs of suberoylanilide hydroxamic acid
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2014年06月20日