发明Breast tumor treatment with anti-CXCR1 compositions

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著录项目

申请号 US20090616579 申请日 2009年11月11日 最早公开日 2010年06月03日 所属国家/地区 美国
公开号及公开日 授权日 2015年01月27日 说明书附图
申请人 UNIV MICHIGAN (美国)  
发明人 WICHA MAX S   GINESTIER CHRISTOPHE  
优先权 US20080113458P   20081111US20090616579   20091111
专利分类号 A61K39/395   A01N37/18   A01N43/02   A01N43/16   G01N33/574   A61K31/18   A61P35/00   C12N5/095   C12Q1/04  
代理机构 代理人 Casimir Jones, S.C.  

名称及摘要

抗 cxcr1 组合物以及方法
本发明提供方法,用于治疗癌症通过服用 il8 - cxcr1 途径抑制剂(,例如,一反 cxcr1 抗体或 repertaxin )仅或结合附加化学治疗剂,以便非 tumorigenic 以及 tumorigenic 癌症细胞患者中由于。 本发明也提供组合物以及方法,用于探以及隔离固体肿瘤干细胞中患者(,例如,基于存在 cxcr1 或 fbxo21 )。
Breast tumor treatment with anti-CXCR1 compositions
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional chemotherapeutic agent such that non-tumorigenic and tumorigenic cancer cells in a subject are killed. The present invention also provides compositions and methods for detecting the presence of and isolating solid tumor stem cells in a patient (e.g., based on the presence of CXCR1 or FBXO21).

同族及引用

同族专利 (37) 引用其他专利(5) 被其他专利引用(64)

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法律状态历史( 到官方网站查询 )

2009年11月18日 us_as 转让(新专利权人: NATIONAL INSTITUTES OF HEALTH (NIH),U.S. DEPT. OF
更多信息: CONFIRMATORY LICENSE;ASSIGNOR:UNIVERSITY OF MICHIGAN;REEL/FRAME:023536/0383
生效日期: 20091117)
2010年02月01日 us_as 转让(新专利权人: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,MICHIGAN
更多信息: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WICHA,MAX S.;GINESTIER,CHRISTOPHE;REEL/FRAME:023877/0004
生效日期: 20081112)
2010年02月01日 us_as 转让(新专利权人: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,MICHIGA
更多信息: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WICHA,MAX S.;GINESTIER,CHRISTOPHE;REEL/FRAME:023877/0004
生效日期: 20081112)
2010年05月06日 us_as 转让(新专利权人: NATIONAL INSTITUTES OF HEALTH (NIH),U.S. DEPT. OF
更多信息: CONFIRMATORY LICENSE;ASSIGNOR:UNIVERSITY OF MICHIGAN;REEL/FRAME:024344/0086
生效日期: 20091117)
2010年05月06日 us_as 转让(新专利权人: NATIONAL INSTITUTES OF HEALTH (NIH),U.S. DEPT. OF
更多信息: CONFIRMATORY LICENSE;ASSIGNOR:UNIVERSITY OF MICHIGAN;REEL/FRAME:024344/0198
生效日期: 20091117)
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