发明Anti-ADDL antibodies and uses thereof

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申请号 US20100828411 申请日 2010年07月01日 最早公开日 2010年10月28日 所属国家/地区 美国
公开号及公开日 授权日 2012年03月06日 说明书附图
申请人 ACTON PAUL (美国)  
AN ZHIQIANG (美国)  
BETT ANDREW J (美国)  
BREESE ROBERT (美国)  
CHANG LEI (美国)  
DODSON ELIZABETH CHEN (美国)  
KINNEY GENE (美国)  
KLEIN WILLIAM (美国)  
LAMBERT MARY P (美国)  
LIANG XIAOPING (美国)  
SHUGHRUE PAUL (美国)  
STROHL WILLIAM R (美国)  
VIOLA KRISTEN (美国)  
发明人 ACTON PAUL   AN ZHIQIANG   BETT ANDREW J   BREESE ROBERT   CHANG LEI   DODSON ELIZABETH CHEN   KINNEY GENE   KLEIN WILLIAM   LAMBERT MARY P   LIANG XIAOPING   SHUGHRUE PAUL   STROHL WILLIAM R   VIOLA KRISTEN  
优先权 US20040621776P   20041025US20050652538P   20050214US20050695528P   20050630US20050695526P   20050630US20050256332   20051021US20100828411   20100701
专利分类号 A61K39/395   C07K16/18   G01N33/53   C07K16/00   C12N5/02  
代理机构 代理人

名称及摘要

抗 addl 抗体及其用途
本发明涉及抗体差分地识别多维的吻合 a 和 bgr ;-衍生扩散配位体,也称为 addls 。 本发明的抗体可区分阿尔茨海默病情以及控制人脑提取液以及可用于方法,用于检测 addls 以及诊断阿尔茨海默病情。 本抗体也块结合 addls 以神经元,组件 addls ,以及τ磷酸化以及有可用于方法,用于防止以及处理病情关联可溶性低聚物淀粉和 bgr ;1-42。
Anti-ADDL antibodies and uses thereof
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

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