发明Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses

pdf收藏

著录项目

申请号 US201113176866 申请日 2011年07月06日 最早公开日 2013年10月03日 所属国家/地区 美国
公开号及公开日 授权日 2014年03月04日 说明书附图
申请人 DAI DONGCHENG (美国)  
BOLKEN TOVE C (美国)  
HRUBY DENNIS E (美国)  
BAILEY THOMAS R (美国)  
SIGA TECHNOLOGIES INC (美国)  
发明人 DAI DONGCHENG   BOLKEN TOVE C   HRUBY DENNIS E   BAILEY THOMAS R  
优先权 US20040632990P   20041206WO2005US43931   20051206US20070653972   20070117US201113176866   20110706
专利分类号 A61K31/166   C07C233/64   A61K31/175   A61K31/18   A61K31/277   A61K31/40   A61K31/415   A61K31/433   A61K31/5377   A61K31/538   A61K31/675   C07C281/06  
代理机构 代理人

名称及摘要

磺酰基氨基脲、羰基氨基脲、氨基脲和脲、其药物组合物和治疗出血热病毒的方法,包括治疗与沙粒病毒相关的感染
公开了通过给予治疗有效量的某些新的磺酰基氨基脲、羰基氨基脲、氨基脲、脲和相关化合物治疗病毒感染的化合物、方法和药物组合物。还公开了制备该化合物的方法和使用该化合物的方法和其药物组合物。尤其是,公开了例如由出血热病毒所引起的病毒感染的治疗和预防,出血热病毒包括但不局限于:沙粒病毒Arenaviridae(Junin、Machupo、Guanarito、Sabia、Lassa、Tacaribe、Pinchinde和VSV),丝状病毒Filoviridae(埃博拉和马尔堡病毒),黄热病毒Flaviviridae(黄热病,鄂木斯克出血热和贾萨努尔森林热病毒),和布尼亚科病毒Bunyaviridae(流行性肝炎)。
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pinchinde, and VSV), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

同族及引用

同族专利 (13) 引用其他专利(28) 被其他专利引用(51)

CA2674967A1 SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
AU2008257428A1 Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
WO2008147474A8 SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
IN4156CHENP2009A SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATES WITH ARENAVIRUSES
EP2124921A4 SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
CN101641092A 磺酰基氨基脲、羰基氨基脲、氨基脲和脲、其药物组合物和治疗出血热病毒的方法,包括治疗与沙粒病毒相关的感染
KR20100028017A SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
JP2010526025A 【Title of corresponding document:CA2674967A1】 SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
US7994221B2 Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
MX2009007687A SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES.
US8658697B2 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US8664274B2 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
BRPI0806920A2 【Title of corresponding document:CA2674967A1】 SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
Anti-arenaviral compounds
Antiviral drugs for treatment of arenavirus infection
Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
Antiviral drugs for treatment of arenavirus infection
Antiviral drugs for treatment of arenavirus infection
Antiviral drugs for treatment or prevention of dengue infection
Antiviral drugs for treatment of arenavirus infection
Anti-viral drugs for treatment of arenavirus infection
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
Antiviral drugs for treatment of arenavirus infection
Anti-arenaviral compounds
Anti-arenaviral compounds
Antiviral drugs for treatment of arenavirus infection
Antiviral drugs for treatment of arenavirus infection
Small molecule inhibitors of ebola and lassa fever viruses
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with Arenaviruses
Antiviral drugs for treatment of Arenavirus infection
Antiviral drugs for treatment or prevention of dengue infection
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
Antiviral drugs for treatment of Arenavirus infection
Hybrid vehicle drive system and method using split shaft power take off
Hybrid vehicle drive system and method and idle reduction system and method
Hybrid vehicle drive system and method for fuel reduction during idle
SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES
Substituted triazolinones.
Substituted triazolinones.
Substituted triazolones.
AMIDINOPHENYLALANINE DERIVATIVE
FLUORO-SUBSTITUTED BENZOYLUREAS AND HARMFUL ORGANISM CONTROLLER
Compositions containing synthetic soil-extract materials and medicaments based thereon
Substituted semicarbazone arthropodicides
Amidinophenylalanine derivatives, process for their preparation, their use and compositions containing them
Herbicidal substituted triazolones
Herbicidal substituted triazolinones
4-alkyl and aryl semicarbazides as oxygen scavengers
Herbicidal sulphonylaminocarbonyltriazolinones having substituents bonded via oxygen of the formula
Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid
Synthetic soil-extract materials and medicaments for hemorrhagic fever viruses based thereon
Treatment of inflammation-associated disorders using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
Modulation of pathogenicity
Sodium channel blocker compositions and the use thereof
Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
Anti-arenaviral compounds
Antiviral drugs for treatment of arenavirus infection
Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
Antiviral drugs for treatment of arenavirus infection
Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
Antiviral drugs for treatment of arenavirus infection
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
SUBSTITUTED PYRROLIDONE, THIAZOLIDONES OR OXAZOLIDONES AS HERBICIDES
INSECTICIDAL FLUORO-SUBSTITUTED BENZOYLUREAS
PROCESS FOR PREPARING SYNTHETIC SOIL-EXTRACT MATERIALS AND MEDICAMENTS BASED THEREON
AZAPEPTIDE ACIDS AS CELL ADHESION INHIBITORS
NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS
NOVEL ALANYL-AMINO PEPTIDASE INHIBITORS FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL, AND OTHER DISEASES
5-AZA-7-DEAZAPURINE NUCLEOSIDES FOR TREATING FLAVIVIRIDAE
COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
COMPOUNDS AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES
ANTI-ARENAVIRAL COMPOUNDS
ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
CHEMICALS, COMPOSITIONS, AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
CHEMICALS, COMPOSITIONS, AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
SULFONYL SEMICARBAZIDES, CARBONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
ANTIVIRAL DRUGS FOR TREATMENT OR PREVENTION OF DENGUE INFECTION
ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION
SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES

法律状态历史( 到官方网站查询 )

2011年12月12日 us_as 转让(新专利权人: NATIONAL INSTITUTES OF HEALTH (NIH),U.S. DEPT. OF
更多信息: CONFIRMATORY LICENSE;ASSIGNOR:SIGA TECHNOLOGIES,INC.;REEL/FRAME:027364/0451
生效日期: 20111107)
2012年02月16日 us_as 转让(新专利权人: NATIONAL INSTITUTES OF HEALTH (NIH),U.S. DEPT. OF
更多信息: CONFIRMATORY LICENSE;ASSIGNOR:SIGA TECHNOLOGIES,INC.;REEL/FRAME:027716/0093
生效日期: 20111107)
2012年12月31日 us_as 转让(新专利权人: GE CAPITAL EQUITY INVESTMENTS,INC. C/O GE HEALTHC
更多信息: SECURITY AGREEMENT;ASSIGNOR:SIGA TECHNOLOGIES,INC.;REEL/FRAME:029557/0771
生效日期: 20121231)
2014年08月14日 us_as 转让(新专利权人: SIGA TECHNOLOGIES INC.,NEW YORK
更多信息: RELEASE OF SECURITY INTEREST;ASSIGNOR:GENERAL ELECTRIC CAPITAL CORPORATION;REEL/FRAME:033544/0324
生效日期: 20140814)
2014年08月22日 us_as 转让(新专利权人: KINETA FOUR LLC,WASHINGTON
更多信息: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SIGA TECHNOLOGIES INC.;REEL/FRAME:033588/0427
生效日期: 20140818)
2015年04月02日 us_as 转让(新专利权人: SIGA TECHNOLOGIES,INC.,NEW YORK
更多信息: RELEASE BY SECURED PARTY;ASSIGNOR:GENERAL ELECTRIC CAPITAL CORPORATION,AS AGENT;REEL/FRAME:035319/0001
生效日期: 20150305)
2017年10月16日 us_fepp (更多信息: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.))
2018年04月02日 us_laps 由于未缴纳维持费致失效(更多信息: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.))

更新记录

2014年06月20日